Endocrine Abstracts

Introduction: Recent studies suggested that plasma levels of osteocalcin (OC) were negatively associated with both fat mass and plasma glucose. These findings may suggest that endocrine function of the osteoblast-derived osteocalcin on fat mass/glucose homeostasis in mice also might exist in humans. The aim of this study was to determine if osteocalcin has any effect on fat distrubution in different parts of body.Methods: Eighty-six obese premenapousal w...

Introduction: It has been demonstrated that there are differences in the effect of body mass index (BMI) on the serum 25-hydroxyvitamin D levels (25-OH D); differences appeared stronger in subjects with higher BMI. In this study we aimed to assess the association between 25-OH D status and body fat distribution and caratid intima medai thickness.Methods: 86 obese premenapousal women (aged 17–55 years) and 56 women with normal BMI took part in this s...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, chronic disorder, with classical clinical features caused by excess GH and consequent raised levels IGF1 and is associated with increased morbidity and mortality. Early diagnosis of the disease is very important for patient survival. Fetuin-A is a plasma glycoprotein that is produced by hepatocytes and it is the most important systemic calcification inhibitor. The p...

Introduction: Generously supported by IPSEN)-->Pregnancy is rare in patients with Cushing’s syndrome (CS) because of hypercortisolemia, hyperandrogenemia, and/or hyperprolactinemia. Diagnostic tests for CS have become less reliable due to the physiological changes in the hypothalamo-pituitary adrenal (HPA) axis during gestation. Some of these changes may persist until the 5th postpartum week. We report a case of Cushing...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, insidious, and potentially life-threatening condition. Patients with acromegaly have an increased morbidity and mortality for cardiovascular diseases. However, data on coronary heart disease and atherosclerosis are controversial in patients with acromegaly. Measurement of carotid intima media thickness (cIMT) with carotid doppler ultrasonography is a useful determin...

Introduction: Acromegaly is a rare disease that is most often caused by a GH secreting pituitary tumor. Apelin, a newly discovered peptide known as an endogenous ligand for its receptor (APJ) is a cardiac positive inotropic factor that has also hypotensive effects. The apelin and its receptor functions have not entirely been understood yet. The physiological importance of apelin, in acromegaly remains obscure.The aim of this study was to investigate the ...